Fasalka Farmasiga Nadiifinta Sare 1421373-66-1 Mesylate-AZD9291 ee Daaweynta Kansarka
Alaabtamagac | AZD-9291 mesylate |
La mid ah | N-[2-[[2- (Dimethylamino) ethyl] methylamino]-4-methoxy-5-[[4- (1-methyl-1H-indol-3-yl) -2-pyrimidinyl] amino] phenyl] - 2-propenamide methanesulfonate (1:1) |
CAS Maya. | 1421373-66-1 |
Muuqashada | Caddaan ilaa khafiif huruud ah budo adag |
Qaanuunka molecular | C28H33N7O2.CH4O3S |
Miisaanka Molecular | 595.71 |
Isticmaalka | Darajada daawada ama ujeedada cilmi baarista |
Baakad | Sida ku cad codsigaaga |
Kaydinta | Ku kaydi weel cidhiidhi ah oo iftiin u adkaysta meel qabow |
AZD-9291 mesylateCAS:1421373-66-1 | ||
Items | Standeriyada | Rnatiijada |
Muuqashada | Caddaan ilaa khafiif huruud ah budo adag | budo adag oo huruud ah oo khafiif ah |
Iilkeed | By IR | U hogaansama |
By HPLC | U hogaansama | |
Solubility | Ku milmay Dimethylsulfoxide, wax yar ku milma Ethanol iyo Acetonitrile, oo leh pH ku-tiirsanaanta aqueous | U hogaansama |
Waxyaabaha Biyaha (KF) | ≤ 1.00% | 0.42% |
Hadhaaga dabka | ≤ 0.10% | 0.05% |
HfududMetal | ≤20pm | U hogaansama |
Mesylate | 15.20% ~ 18.20% | 15.90% |
Xalalka Haraaga ah | Acetonitrile: ≤410ppm | ND |
Acetone: ≤5000ppm | ND | |
Tetrahydrofuran: ≤720ppm | ND | |
RfarxaySwalxaha | Midka ugu badan ee wasakhda ah: ≤0.20% | 0.17% |
Wadarta wasakhda: ≤1.00% | 0.25% | |
Cabbirka Qaybta | D90: ≤100μm | 57.97% |
Adheh (HPLC ku salaysan qalajinta) | 98.00% ~ 102.00% | 99.80% |
Heerka Tixraaca | In-guriga Standard |
Macluumaadka Shirkadda
√ Waayo-aragnimada buuxda ee lakabka maamulka ee warshadda iyo farsamayaqaannada raacsan; √ Tayada had iyo jeer waa tixgelinteena ugu sareysa, nidaamka QC adag; √ 11 sano oo khibrad u leh kooxda iibka dhoofinta; √ shaybaadhka R&D ee madaxa banaan; √ Laba aqoon-is-weydaarsiyo GMP-dheer oo saxeexan; √ Khayraadka hodanka ah ee warshado badan oo shaqo la'aan ah oo loogu talagalay mashruuc la habeeyey; √ Kooxda shaqada oo hufnaan sare leh oo leh waddo joogto ah.Halkan ku qor fariintaada oo noo soo dir