Fasalka Farmasiga Nadiifinta Sare 877399-52-5 Crizotinib ee Daaweynta Ka-hortagga Kansarka
| Alaabtamagac | Crizotinib |
| La mid ah | PF-02341066;3-[(1R) -1- (2,6-Dichloro-3-fluorophenyl) ethoxy]-5-[1- (4-piperidinyl) -1H-pyrazol-4-yl] pyridin-2-amine;PF 2341066 |
| CAS Maya. | 877399-52-5 |
| Muuqashada | Caddaan iyo budo crystalline ah |
| Qaanuunka molecular | C21H22Cl2FN5O |
| Miisaanka Molecular | 450.34 |
| Isticmaalka | Darajada daawada ama ujeedada cilmi baarista |
| Baakad | Sida ku cad codsigaaga |
| Kaydinta | Ku kaydi weel cidhiidhi ah oo iftiin u adkaysta meel qabow |
| CrizotinibKiiska: 877399-52-5 | ||
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Caddaan iyo budo crystalline ah | Budada crystalline cad |
| Aqoonsiga | H-NMR, MS | U hogaansama |
| Xalalka Haraaga ah | isopropanol≤0.5% EtOAc≤0.5% THF≤0.072% n-Heptane≤0.5% Toluene≤0.5% | 0.3% ND ND ND ND ND |
| Biraha culus | ≤10pm | U hogaansama |
| Biyaha ku jira | £0.5% | 0.3% |
| Hadhaaga dabka | £0.5% | 0.05% |
| Enantiomer | £0.1% | LOQ |
| Xumaanta La Xidhiidha ee HPLC | Nijaasta keliya≤0.1% Wadarta wasakhda ≤1.0% | 0.05% 0.12% |
| Daahirnimada (HPLC) | ³99.0% | 99.88% |
Macluumaadka Shirkadda
√ Waayo-aragnimada buuxda ee lakabka maamulka ee warshadda iyo farsamayaqaannada raacsan; √ Tayada had iyo jeer waa tixgelinteena ugu sareysa, nidaamka QC adag; √ 11 sano oo khibrad u leh kooxda iibka dhoofinta; √ shaybaadhka R&D ee madaxa banaan; √ Laba aqoon-is-weydaarsiyo GMP-dheer oo saxeexan; √ Khayraadka hodanka ah ee warshado badan oo shaqo la'aan ah oo loogu talagalay mashruuc la habeeyey; √ Kooxda shaqada oo hufnaan sare leh oo leh waddo joogto ah.
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