Waqtigan xaadirka ah, waxaa jira ilaa 81 nooc oo dawooyinka ka hortagga burooyinka ah oo caadi ahaan loo isticmaalo kiliinikada.1. Daawooyinka ka hortagga burooyinka waxaa loo kala saaraa iyadoo loo eegayo meesha ay ka yimaadaan iyo habka ay wax u qabtaan.Guud ahaan waxaa loo qaybiyaa dawooyinka alkylating, antimetabolites, antibiyootiga, dhirta, hormoonnada iyo daawooyinka kale.Daawooyinka kale waxaa ka mid ah platinum, asparaginase, daawooyinka daawaynta la beegsaday, iwm., marka laga reebo reagents noolaha iyo daaweynta hidda-socodka.Kala soocidaani ma soo koobi karto horumarka hadda jira ee daawooyinka ka hortagga burooyinka.Marka labaad, kala soocida kale waxay ku salaysan tahay bartilmaameedyada molecular ee daroogooyinka, kuwaas oo loo qaybiyay qaybo badan.Qaybta koowaad waa dawooyinka ku shaqeeya qaab-dhismeedka kiimikaad ee DNA-da, sida xeryahooda alkylating ama platinum.Qaybta labaad waa dawooyinka saameeya abuurka nucleic acid, sida antimetabolites.Qaybta saddexaad waa dawada ku shaqeysa qaabka DNA-da, saameyn ku yeelata qorista iyo xakameynta DNA-da, waxayna joojisaa isku-dhafka RNA iyadoo ku tiirsan RNA polymerase.Qaybta afraad waa dawooyin saameeya isku-dhafka borotiinka, sida paclitaxel, vinblastine iyo wixii la mid ah.Qaybta ugu danbeysa waa noocyada kale ee dawooyinka, sida hormoonnada, aspartic acid, daawoyinka daawaynta ee bartilmaameedka ah, iwm., laakiin daawooyinka hadda jira ee ka hortagga burooyinka ayaa si xawli ah u koraya, qaybaha kore ma soo koobi karaan daawooyinka jira iyo daawooyinka ku saabsan. si ay u galaan rugta caafimaadka.."

Waqtigan xaadirka ah, waxaa jira dawooyin badan oo ka hortagga burooyinka oo ku jira waxqabadka kiliinikada.Tusaale ahaan,oxaliplatin, fluorouracil, iyo irinotecan waxaa loo isticmaali karaa burooyinka caloosha iyo mindhicirka.Bukaanka qaba kansarka caloosha waxaa lagu daweyn karaa daawooyin sidacisplatiniyopaclitaxel.Guud ahaan, kansarrada kala duwan ayaa doorta dawooyin kala duwan.Intaa waxaa dheer, bukaannada kansarka sidoo kale waxaa lagu daweyn karaa dawooyinka la beegsanayo molecular, sida erlotinib, osimertinib, cetuximab iyo daawooyin kale.

Daawooyinka caadiga ah ee ka hortagga burooyinka ee keena CIPN waxaa ka mid ahPaclitaxel, Platinum, Vinblastine,Methotrexate, Fluorouracil, Ifosfamide,Cytarabine, Fludarabine, Thalidomide,Bortimiazoleiyo wixi la mida.

Paclitaxel waxay isticmaashaa factor koritaanka dareemayaasha si loo yareeyo ama loo rogo neurotoxicity;cisplatin waxay isticmaashaa glutathione la dhimay iyo amifostine si looga hortago neuropathy ay keento;oxaliplatin ma la xiriirto kicinta qabow inta lagu jiro isticmaalka si looga hortago kicinta qabow ee saameeya dareemayaasha durugsan Kicinta, isticmaalka isku-darka kalsiyum-magnesium waxay yareyn kartaa dhacdooyinka iyo xoojinta calaamadaha neurotoxicity ee ba'an, iyo dib u dhigista dhacdooyinka isugeynta neuropathy;ifosfamide waxay dooran kartaa methylene buluug si looga hortago neurotoxicity;u isticmaal thiamine fluorouracil waxay ka hortagi kartaa neerfaha Saamaynta sunta ah.