Nadiifinta Sare 540737-29-9 Tofacitinib citrate for JAK Pathway Inhibitor
Alaabtamagac | Tofacitinib Citrate |
La mid ah | (3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo [2,3-d] pyrimidin-4-yl-3-piperidinamine 2-hydroxy-1,2,3 -propanetricarboxylate;CP 690500-10;CP 690550-10;(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo [2,3-d]pyrimidin-4-ylamino) -beta-oxo-1-piperidinepropanenitrile 2-Hydroxy-1,2,3-propanetricarboxylate |
CAS Maya. | 540737-29-9 |
Muuqashada | Ka saar caddaan ilaa budo cad |
Qaanuunka molecular | C16H20N6OC6H8O7 |
Miisaanka Molecular | 504.50 |
Codsiga | Darajada daawada ama ujeedada cilmi baarista |
Baakad | Sida ku cad codsigaaga |
Kaydinta | Ku kaydi weel cidhiidhi ah oo iftiin u adkaysta meel qabow |
Tofacitinib Citrate (CAS #540737-29-9) | ||
WAXYAABAHA | HEERARKA | NATIIJADA |
Muuqashada | Ka saar caddaan ilaa budo cad | Ka saar budada cad |
Aqoonsiga | HPLC;IR;HNMR | U hogaansama |
Solubility | Ku milmay DMSO 100mg/ml, aad ugu liidata ee ethanol, si yar ugu milmay biyaha iwm. | U hogaansama |
Khasaare xagga qalajinta | ≤0.5% | 0.12% |
Hadhaaga dabka | ≤0.1% | 0.05% |
Biraha culus | ≤10pm | U hogaansama |
Walxaha laxidhiidha | Diastereomer (RS+SR) ≤0.1% Hal wasakh ≤0.15% Wadarta wasakhda ≤1.0% | 0.05% 0.14% 0.18% |
Enantiomorphism Isomers | ≤0.2% | U hogaansama |
Xalalka Haraaga ah | Ethanol ≤5000ppm Methanol ≤3000ppm Toluene ≤890ppm | U hogaansama |
Mawduuca Citrate | 36.2% ~ 40% | 37.8% |
daahirnimo | ≥99.0% | 99.38% |
Qiimayn | 60.68% ~ 63.16% ee Tofacitinib INN 98% ~ 102% ee Tofacitinib Citrate INN | 62.04%
99.12% |
Gabagabo: Waa waafaqsan |
Macluumaadka Shirkadda
√ Waayo-aragnimada buuxda ee lakabka maamulka ee warshadda iyo farsamayaqaannada raacsan; √ Tayada had iyo jeer waa tixgelinteena ugu sareysa, nidaamka QC adag; √ 11 sano oo khibrad u leh kooxda iibka dhoofinta; √ shaybaadhka R&D ee madaxa banaan; √ Laba aqoon-is-weydaarsiyo GMP-dheer oo saxeexan; √ Khayraadka hodanka ah ee warshado badan oo shaqo la'aan ah oo loogu talagalay mashruuc la habeeyey; √ Kooxda shaqada oo hufnaan sare leh oo leh waddo joogto ah.Halkan ku qor fariintaada oo noo soo dir