Cudurada difaaca jirka, kuwaas oo ah noocyo kala duwan oo u badan kuwa soo noqnoqda iyo cudurrada halista ah, ayaa ah mid ka mid ah jihooyinka muhiimka ah ee horumarinta daroogada hadda.JAK-STAT waa mid ka mid ah dhowr dariiqooyinka difaaca jirka ee la xaqiijiyay, gaar ahaan JAK inhibitors.Daawooyin badan,sida tofacitinib, ayaa la suuq geeyey caalamka oo dhan.

Bartilmaameedka JAK ayaa la sameeyay wax ka yar 20 sano, laakiin hadda ku dhawaad ​​​​7 nooc ayaa loo oggolaaday suuqgeyn.Calaamaduhu waxay u badan yihiin buro iyo cudurrada is-difaaca, iyo calaamadaha la sifeeyay waxay u badan yihiin dhuuxa lafta fibrosis iyo rheumatoid arthritis-ka.Kuwa soo socdaa waxay diiradda saarayaan JAK inhibitor-ka ugu horreeya (tofacitinib) ee daaweynta rheumatoid arthritis-ka.

Tofacitinib waa unug yar oo afka laga qaato JAK inhibitor oo uu sameeyay Pfizer.Waxay leedahay xulashada JAK wanaagsan.Bishii Nofembar 2012, US FDA waxay ansixisay tofacitinib citrate si loogu daweeyo methotrexate ku filan ama jawaab-celinta daawaynta.Alaabtani waa JAK inhibitorkii ugu horreeyay ee ay ansixisay FDA si loogu daweeyo rheumatoid arthritis-ka.Waqtigan xaadirka ah, marka lagu daro tilmaamayaasha la ansixiyay, tofacitinib ayaa sidoo kale laga baarayaa waxtarkeeda spondylitis ankylosing, atopic dermatitis, keratoconjunctivitis sicca iyo cudurka Crohn.Marka la eego iibka caalamiga ah, iibka sannadlaha ah ee tofacitinib ee 2017 wuxuu ka badnaa US $ 1 bilyan, iibka sannadlaha ah ee 2019 wuxuu gaadhay US $ 2.242 bilyan.

Wadooyinka kala duwan ee synthetic waxay saameyn weyn ku yeelan doonaan wax soo saarka iyo tayada API-yada.Isku-dubaridkeena tofacitinib citrate waxay ka fogaanaysaa dariiqa patented.Waddada synthetic waxay u baahan tahay kharash yar oo alaabta ceeriin ah, wax-soo-saar sare, wasakhda keliya iyo nadiifinta waxaa lagu xakameyn karaa ilaa xad macquul ah, ama waxaa beddeli kara macaamiisha.Markaa noo suurtagelisaa inaan faa'iido muuqata ku yeelanno suuqa.Hadda awooddayadu waxay noqon kartaa 50kg bishii, iyo tofacitinib citrate horayba loo dhoofiyay USA, Mexico, Franch, Bangladesh, iwm.